COATING PERSISTENT LUMINESCENCE NANOPARTICLES WITH HYDROPHILIC POLYMERS FOR IN VIVO IMAGING


Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts

Abstract Background Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo contain an unknown mix of mouse and human cells.Evaluation of drug activity can be confounded by samples containing large amounts of contaminating mouse tissue.We have developed a real-time quantitative polymerase chain reaction (qPCR) assay using

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